Exercise copes with prolonged stress-induced impairment of spatial memory performance by endoplasmic reticulum stress
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چکیده
منابع مشابه
Exercise copes with prolonged stress-induced impairment of spatial memory performance by endoplasmic reticulum stress
The present study demonstrates that prolonged restraint administration for 21 days caused memory impairment and induced hippocampal endoplasmic reticulum (ER) stress-mediated apoptosis. On the contrary, this change was revered by treadmill running for 8 weeks. Repeated psychological stress caused an increase in escape latency time in the water maze test, accompanied by the induction of glucose-...
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The efficient functioning of the endoplasmic reticulum (ER) is essential for most cellular activities and survival. Conditions that interfere with ER function lead to the accumulation and aggregation of unfolded proteins. ER transmembrane receptors detect the onset of ER stress and initiate the unfolded protein response (UPR) to restore normal ER function. If the stress is prolonged, or the ada...
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endoplasmic reticulum (er) stress provides abnormalities in insulin action, inflammatory responses, lipoprotein b100 degradation and hepatic lipogenesis. excess accumulation of triglyceride in hepatocytes may also lead to disorders such as non-alcoholic fatty liver disease (nafld) and nonalcoholic steatohepatitis (nash). opioid peptides are involved in triglyceride and cholesterol dysregulat...
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Recent studies showed that cyanobacteria-derived microcystin-leucine-arginine (MCLR) can cause hippocampal pathological damage and trigger cognitive impairment; but the underlying mechanisms have not been well understood. The objective of the present study was to investigate the mechanism of MCLR-induced cognitive deficit; with a focus on endoplasmic reticulum (ER) stress. The Morris water maze...
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The B-cell lymphoma 2 (BCL-2)-related ovarian killer (BOK) shares sequence homology with the proapoptotic BCL-2 family members BAX and BAK. However, Bok cells are not protected from classic apoptotic triggers and evidence for a proapoptotic role of BOK is derivedmostly from overexpression studies (1). BOK localizes preferentially to the endoplasmic reticulum (ER) membrane, where it interacts wi...
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ژورنال
عنوان ژورنال: Journal of Exercise Nutrition & Biochemistry
سال: 2015
ISSN: 2233-6834,2233-6842
DOI: 10.5717/jenb.2015.15080705